SCHEMBL27366936

SCHEMBL27366936

CC(C)n1cc(C(=O)Nc2ccc(Oc3ncnc4oc(-c5cnn(C)c5)c(-c5cccc(CN(C)C)c5)c34)cc2)c(=O)n(-c2ccccn2)c1=O

nearest known ligand 0.65

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
AXL P30530 19/20 0.65
MERTK Q12866 18/20 0.65
TYRO3 Q06418 4/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27366941 0.93 AXL (0.72) AXLMERTKTYRO3
SCHEMBL27366839 0.93 MERTK (0.68) AXLMERTKTYRO3
SCHEMBL27366846 0.90 MERTK (0.64) AXLMERTKTYRO3
SCHEMBL27366818 0.89 MERTK (0.67) AXLMERTKTYRO3
SCHEMBL27366841 0.86 MERTK (0.75) AXLMERTKTYRO3
SCHEMBL27366829 0.83 MERTK (0.66) AXLMERTKTYRO3
SCHEMBL27367237 0.83 MERTK (0.74) AXLMERTKTYRO3
SCHEMBL27367037 0.82 MERTK (0.83) AXLMERTKTYRO3
SCHEMBL27366825 0.82 MERTK (0.73) AXLMERTKTYRO3
SCHEMBL27367121 0.81 MERTK (0.76) AXLMERTKTYRO3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024039842-A2 INHIBITORS OF TAM RECEPTORS NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2024-02-22 WO disclosed