Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.54 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.46 |
| ▸ | CFTR | P13569 | 6/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24311004 | 0.88 | NOTUM (0.51) | NOTUMSOS1CFTRPTPN2MAPT | |
| SCHEMBL8609014 | 0.88 | NOTUM (0.43) | NOTUMSOS1CFTR | |
| SCHEMBL30012935 | 0.84 | NOTUM (0.52) | NOTUMSOS1CFTRPTPN2MAPT | |
| SCHEMBL23727980 | 0.84 | NOTUM (0.52) | NOTUMSOS1CFTRPTPN2MAPT | |
| SCHEMBL27366274 | 0.83 | CFTR (0.46) | NOTUMSOS1CFTRMAPTALDH1A1 | |
| SCHEMBL8539026 | 0.81 | NOTUM (0.60) | NOTUMSOS1CFTRPTPN2MAPT | |
| SCHEMBL24525533 | 0.80 | CFTR (0.64) | NOTUMSOS1CFTRMAPTALDH1A1 | |
| SCHEMBL31565668 | 0.80 | CFTR (0.64) | NOTUMSOS1CFTRMAPTALDH1A1 | |
| SCHEMBL23526150 | 0.80 | NOTUM (0.55) | NOTUMSOS1CFTRPTPN2MAPT | |
| SCHEMBL21822936 | 0.80 | NOTUM (0.55) | NOTUMSOS1CFTRPTPN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1064955-C | Fluorine-containing benzoylguanidines | MERCK PATENT GMBH (DE) | 2001-04-25 | — | — | CN | disclosed |
| CN-1143632-A | Fluorine-containing benzoylguanidines | MERCK PATENT GMBH (DE) | 1997-02-26 | — | — | CN | disclosed |