SCHEMBL27367434

SCHEMBL27367434

Cc1n[nH]c2nc(-c3ccc(N)cc3)nc(OC3CCN(C(C)C)CC3)c12

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SGK1 O00141 11/20 0.49
HRH3 Q9Y5N1 9/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27323644 0.85 SGK1 (0.60) SGK1
SCHEMBL27323593 0.84 SGK1 (0.58) SGK1
SCHEMBL27365113 0.84 SGK1 (0.48) SGK1HRH3
SCHEMBL27360112 0.83 SGK1 (0.47) SGK1HRH3
SCHEMBL27323588 0.82 SGK1 (0.56) SGK1
SCHEMBL27323591 0.82 SGK1 (0.56) SGK1
SCHEMBL27323594 0.81 SGK1 (0.55) SGK1
SCHEMBL27324351 0.81 SGK1 (0.60) SGK1
SCHEMBL27326022 0.80 SGK1 (0.55) SGK1
SCHEMBL29738867 0.79 SGK1 (0.60) SGK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024015055-A1 PYRAZOLO[3,4-D]PYRIMIDIN-6-YL-SULFONAMIDE DERIVATIVES FOR THE INHIBITION OF SGK-1 AND TREATMENT OF CANCER THRYV THERAPEUTICS INC. (CA) 2024-01-18 WO disclosed