SCHEMBL27367461

SCHEMBL27367461

CNc1nc(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(-c3cccc(CN(C)C)c3)c(-c3cnn(C)c3)oc2n1

nearest known ligand 0.82

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MERTK Q12866 20/20 0.82
AXL P30530 19/20 0.82
TYRO3 Q06418 4/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27367624 0.94 MERTK (0.80) MERTKAXLTYRO3
SCHEMBL27367390 0.93 MERTK (0.84) MERTKAXLTYRO3
SCHEMBL27367468 0.92 MERTK (0.82) MERTKAXLTYRO3
SCHEMBL27367464 0.91 MERTK (0.68) MERTKAXLTYRO3
SCHEMBL27365942 0.90 MERTK (1.00) MERTKAXLTYRO3
SCHEMBL32685181 0.90 MERTK (1.00) MERTKAXLTYRO3
SCHEMBL27367397 0.90 MERTK (0.81) MERTKAXLTYRO3
SCHEMBL27367548 0.90 MERTK (0.80) MERTKAXLTYRO3
SCHEMBL27367631 0.85 MERTK (0.67) MERTKAXLTYRO3
SCHEMBL31512155 0.85 MERTK (0.89) MERTKAXLTYRO3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024039842-A2 INHIBITORS OF TAM RECEPTORS NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2024-02-22 WO disclosed