SCHEMBL27367701

SCHEMBL27367701

Cn1cc(-c2oc3ncnc(Oc4ccc(NC(=O)c5cn(C)n(-c6ccc(F)cc6)c5=O)cc4)c3c2-c2cccc(N3CCCCC3=O)c2)cn1

nearest known ligand 0.67

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MERTK Q12866 20/20 0.67
AXL P30530 19/20 0.67
TYRO3 Q06418 4/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27367699 0.91 MERTK (0.81) MERTKAXLTYRO3
SCHEMBL27366943 0.89 MERTK (0.82) MERTKAXLTYRO3
SCHEMBL27366944 0.88 MERTK (0.82) MERTKAXLTYRO3
SCHEMBL27367705 0.86 MERTK (0.72) MERTKAXLTYRO3
SCHEMBL27367174 0.86 MERTK (0.74) MERTKAXLTYRO3
SCHEMBL27367037 0.85 MERTK (0.83) MERTKAXLTYRO3
SCHEMBL27367114 0.85 MERTK (0.70) MERTKAXLTYRO3
SCHEMBL27367122 0.84 MERTK (0.69) MERTKAXLTYRO3
SCHEMBL27367182 0.84 MERTK (0.73) MERTKAXLTYRO3
SCHEMBL27367120 0.83 MERTK (0.74) MERTKAXLTYRO3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024039842-A2 INHIBITORS OF TAM RECEPTORS NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2024-02-22 WO disclosed