Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.39 |
| ▸ | OTC | P00480 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 4/20 | 0.37 |
| ▸ | NOS3 | P29474 | 3/20 | 0.37 |
| ▸ | NOS1 | P29475 | 3/20 | 0.37 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL15941091 | 0.98 | PRCP (0.40) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL1840912 | 0.98 | PRCP (0.40) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL17113848 | 0.98 | PRCP (0.40) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL1840910 | 0.98 | PRCP (0.40) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL28914483 | 0.98 | PRCP (0.40) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL17113850 | 0.98 | PRCP (0.40) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL20242303 | 0.98 | PRCP (0.40) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL27869599 | 0.96 | PRCP (0.40) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL28855814 | 0.96 | PRCP (0.40) | PRCPOTCNOS2NOS3NOS1 | |
| Arginine SCHEMBL8582228 | 0.93 | PRCP (0.38) | PRCPOTCNOS2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1066961-C | Preparing of pharmaceutical with activity of resolution of thrombus by use of agent directly inhibiting thrombin | SANOFI SYNTHELABO (FR) | 2001-06-13 | — | — | CN | disclosed |
| CN-1087015-A | Utilize the direct inhibitor manufacturing of thrombin to have the active medicine of thrombus | SYNTHELABO (FR) | 1994-05-25 | — | — | CN | disclosed |