Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 13/20 | 0.50 |
| ▸ | IRAK4 | Q9NWZ3 | 11/20 | 0.50 |
| ▸ | NRAS | P01111 | 4/20 | 0.46 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | BLK | P51451 | 1/20 | 0.41 |
| ▸ | CCNH | P51946 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24574012 | 1.00 | FLT3 (0.50) | FLT3IRAK4NRASIRAK1LCK | |
| SCHEMBL24542328 | 0.86 | FLT3 (0.46) | FLT3IRAK4NRASIRAK1CDK7 | |
| SCHEMBL24574016 | 0.83 | IRAK4 (0.67) | FLT3IRAK4NRASIRAK1LCK | |
| SCHEMBL27370037 | 0.83 | IRAK4 (0.67) | FLT3IRAK4NRASIRAK1LCK | |
| SCHEMBL24542373 | 0.80 | IRAK4 (0.47) | FLT3IRAK4NRASIRAK1LCK | |
| SCHEMBL25989914 | 0.80 | IRAK4 (0.76) | FLT3IRAK4NRAS | |
| SCHEMBL24231229 | 0.80 | IRAK4 (0.76) | FLT3IRAK4NRAS | |
| SCHEMBL376370 | 0.79 | CCNK (0.42) | FLT3IRAK4CDK7CCNH | |
| SCHEMBL376352 | 0.79 | CCNK (0.42) | FLT3IRAK4CDK7CCNH | |
| SCHEMBL376351 | 0.79 | CCNK (0.42) | FLT3IRAK4CDK7CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023250431-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2023-12-28 | — | — | WO | disclosed |