Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.82 |
| ▸ | FLT3 | P36888 | 19/20 | 0.82 |
| ▸ | CCNA2 | P20248 | 14/20 | 0.82 |
| ▸ | CDK2 | P24941 | 14/20 | 0.82 |
| ▸ | CCNA1 | P78396 | 14/20 | 0.82 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.82 |
| ▸ | CCNK | O75909 | 1/20 | 0.82 |
| ▸ | STK10 | O94804 | 1/20 | 0.82 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.82 |
| ▸ | ABL1 | P00519 | 1/20 | 0.82 |
| ▸ | EGFR | P00533 | 1/20 | 0.82 |
| ▸ | PRKCB | P05771 | 1/20 | 0.82 |
| ▸ | CDK1 | P06493 | 1/20 | 0.82 |
| ▸ | RET | P07949 | 1/20 | 0.82 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.82 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.82 |
| ▸ | FER | P16591 | 1/20 | 0.82 |
| ▸ | PRKCA | P17252 | 1/20 | 0.82 |
| ▸ | ERCC2 | P18074 | 1/20 | 0.82 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zotiraciclib SCHEMBL29392459 | 0.90 | FLT3 (1.00) | JAK2FLT3CCNA2CDK2CCNA1 | |
| Zotiraciclib SCHEMBL29358903 | 0.90 | FLT3 (1.00) | JAK2FLT3CCNA2CDK2CCNA1 | |
| Zotiraciclib SCHEMBL30776189 | 0.90 | FLT3 (1.00) | JAK2FLT3CCNA2CDK2CCNA1 | |
| Zotiraciclib SCHEMBL17595943 | 0.90 | FLT3 (1.00) | JAK2FLT3CCNA2CDK2CCNA1 | |
| Zotiraciclib SCHEMBL823947 | 0.90 | FLT3 (1.00) | JAK2FLT3CCNA2CDK2CCNA1 | |
| SCHEMBL24710255 | 0.88 | JAK2 (0.79) | JAK2FLT3CCNA2CDK2CCNA1 | |
| SCHEMBL824018 | 0.88 | JAK2 (1.00) | JAK2FLT3CCNA2CDK2CCNA1 | |
| SCHEMBL824041 | 0.87 | JAK2 (1.00) | JAK2FLT3CCNA2CDK2CCNA1 | |
| SCHEMBL1108232 | 0.86 | JAK2 (1.00) | JAK2FLT3CCNA2CDK2CCNA1 | |
| SCHEMBL1108229 | 0.86 | JAK2 (1.00) | JAK2FLT3CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054953-A1 | HETEROBIFUNCTIONAL COMPOUNDS AND METHODS OF TREATING DISEASE | HALDA THERAPEUTICS OPCO, INC. (US) | 2024-03-14 | — | — | WO | disclosed |