Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.43 |
| ▸ | RXRA | P19793 | 2/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.43 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.42 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.42 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30273494 | 0.97 | KDM4E (0.50) | KDM4EMAPTTHRBEPHX2DDB1 | |
| SCHEMBL25036594 | 0.97 | KDM4E (0.50) | KDM4EMAPTTHRBEPHX2DDB1 | |
| SCHEMBL29967371 | 0.95 | EPHX2 (0.50) | KDM4EMAPTTHRBEPHX2DDB1 | |
| SCHEMBL23411616 | 0.95 | EPHX2 (0.50) | KDM4EMAPTTHRBEPHX2DDB1 | |
| SCHEMBL27370739 | 0.94 | EPHX2 (0.52) | KDM4EMAPTTHRBEPHX2DDB1 | |
| SCHEMBL30847566 | 0.93 | DDB1 (0.48) | KDM4EMAPTTHRBEPHX2DDB1 | |
| SCHEMBL27371415 | 0.93 | DDB1 (0.48) | KDM4EMAPTTHRBEPHX2DDB1 | |
| SCHEMBL27371417 | 0.93 | KDM4E (0.47) | KDM4EMAPTTHRBEPHX2DDB1 | |
| SCHEMBL27371365 | 0.92 | KDM4E (0.46) | KDM4EMAPTTHRBEPHX2DDB1 | |
| SCHEMBL27370632 | 0.92 | EPHX2 (0.61) | KDM4EMAPTTHRBEPHX2DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024064316-A1 | COMPOUNDS AND COMPOSITIONS AS SMARCA2/4 INHIBITORS AND USES THEREOF | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-03-28 | — | — | WO | disclosed |