Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.42 |
| ▸ | PARP1 | P09874 | 7/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.33 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27362449 | 0.82 | PDE3B (0.52) | PDE3BPDE3APARP1 | |
| SCHEMBL27528568 | 0.82 | PDE3B (0.64) | PDE3BPDE3APARP1SMYD3 | |
| SCHEMBL7342522 | 0.79 | PDE3B (0.66) | PDE3BPDE3APARP1SMYD3 | |
| SCHEMBL27447337 | 0.77 | — | — | |
| SCHEMBL27381477 | 0.74 | — | — | |
| SCHEMBL27447335 | 0.72 | PDE3B (0.41) | PDE3BPDE3A | |
| SCHEMBL27376326 | 0.72 | — | — | |
| SCHEMBL5671394 | 0.70 | PARP1 (0.56) | PDE3BPDE3APARP1SMYD3CECR2 | |
| SCHEMBL27381476 | 0.69 | PDE3B (0.41) | PDE3BPDE3A | |
| SCHEMBL7349308 | 0.69 | PDE3B (0.70) | PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1071427-A | 6-Benzoxazinyl and 6-benzothiazine base-2,3,4,5-tetrahydro pyridazine-3-ketone | ORTHO PHARMA CORP (US) | 1993-04-28 | — | — | CN | disclosed |
| CN-87108354-A | 6-benzoxazinyl and 6-benzothiazinyl-2, 3, 4, 5-tetrahydropyridazin-3-ones | — | 1988-09-21 | — | — | CN | disclosed |