Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WRN | Q14191 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | FPR1 | P21462 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | CETP | P11597 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27377943 | 0.97 | WRN (0.55) | WRNCA1CA2CA7EPHX2 | |
| SCHEMBL27382052 | 0.96 | WRN (0.59) | WRNCA1CA2CA7EPHX2 | |
| SCHEMBL25036931 | 0.93 | WRN (0.59) | WRNCA1CA2CA7EPHX2 | |
| SCHEMBL25036978 | 0.91 | WRN (0.59) | WRNCA1CA2CA7EPHX2 | |
| SCHEMBL27377561 | 0.91 | WRN (0.57) | WRNCA1CA2CA7EPHX2 | |
| SCHEMBL27379356 | 0.90 | WRN (0.56) | WRNCA1CA2CA7EPHX2 | |
| SCHEMBL27378044 | 0.90 | WRN (0.56) | WRNCA1CA2CA7EPHX2 | |
| SCHEMBL27378045 | 0.90 | WRN (0.56) | WRNCA1CA2CA7EPHX2 | |
| SCHEMBL27377743 | 0.89 | WRN (0.57) | WRNKDM4ELMNAMAPTKDR | |
| SCHEMBL31005818 | 0.89 | WRN (0.55) | WRNCA1CA2CA7EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024105553-A1 | BICYCLIC HETEROCYCLES AND THEIR USE AS WRN INHIBITORS | NOVARTIS AG (CH) | 2024-05-23 | — | — | WO | disclosed |