Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 2/20 | 0.43 |
| ▸ | CCND1 | P24385 | 2/20 | 0.43 |
| ▸ | CCND3 | P30281 | 2/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 3/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.37 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.36 |
| ▸ | LCK | P06239 | 2/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.35 |
| ▸ | CCNK | O75909 | 2/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CCNH | P51946 | 1/20 | 0.35 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27392414 | 1.00 | CDK4 (0.43) | CDK4CCND1CCND3CDK6JAK3 | |
| SCHEMBL27213280 | 0.91 | JAK3 (0.40) | CDK4CCND1CCND3CDK6JAK3 | |
| SCHEMBL30906884 | 0.84 | CDK6 (0.47) | CDK4CCND1CCND3CDK6MAPK3 | |
| SCHEMBL27213229 | 0.84 | CDK6 (0.47) | CDK4CCND1CCND3CDK6MAPK3 | |
| SCHEMBL27213248 | 0.80 | CCNE1 (0.38) | CDK4CCND1CCND3CDK6JAK3 | |
| SCHEMBL30906912 | 0.80 | CCNE1 (0.38) | CDK4CCND1CCND3CDK6JAK3 | |
| SCHEMBL27213287 | 0.80 | CCNK (0.45) | CCNKCDK12CCNT1CCNE1CDK2 | |
| SCHEMBL30906921 | 0.80 | CCNK (0.45) | CCNKCDK12CCNT1CCNE1CDK2 | |
| SCHEMBL27392474 | 0.80 | CCNK (0.45) | CCNKCDK12CCNT1CCNE1CDK2 | |
| SCHEMBL30906883 | 0.80 | CCNE1 (0.38) | CDK4CCND1CCND3CDK6JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024077216-A1 | CDK INHIBITORS AND THEIR USE AS PHARMACEUTICALS | PRELUDE THERAPEUTICS INCORPORATED (US) | 2024-04-11 | — | — | WO | disclosed |