Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | MYC | P01106 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.47 |
| ▸ | G6PD | P11413 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27533414 | 0.89 | TSHR (0.53) | TSHRALDH1A1HPGDKDM4EHSD17B10 | |
| Hydrazine SCHEMBL28166056 | 0.89 | TSHR (0.57) | TSHRALDH1A1HPGDKDM4EHSD17B10 | |
| Benzene SCHEMBL27265959 | 0.89 | TSHR (0.61) | TSHRALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL756585 | 0.89 | TSHR (0.61) | TSHRALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL27703149 | 0.89 | TSHR (0.61) | TSHRALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL2431512 | 0.87 | TSHR (0.52) | TSHRALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL10768142 | 0.86 | TSHR (0.59) | TSHRALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL27479457 | 0.86 | TSHR (0.59) | TSHRALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL27552497 | 0.86 | TSHR (0.59) | TSHRALDH1A1HPGDKDM4EHSD17B10 | |
| Fluoride SCHEMBL27323288 | 0.86 | TSHR (0.59) | TSHRALDH1A1HPGDKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1085205-C | Bicyclic amino acids | MERCK PATENT GMBH (DE) | 2002-05-22 | — | — | CN | disclosed |
| CN-1252064-A | Bicyclic amino acids | MERCK PATENT GMBH (DE) | 2000-05-03 | — | — | CN | disclosed |