Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.66 |
| ▸ | CLPP | Q16740 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL192922 | 0.88 | GRM5 (0.82) | GRM5CLPPMEN1KMT2APOLB | |
| SCHEMBL192923 | 0.88 | GRM5 (0.82) | GRM5CLPPMEN1KMT2APOLB | |
| SCHEMBL192774 | 0.81 | GRM5 (0.84) | GRM5CLPPMEN1KMT2APOLB | |
| SCHEMBL192775 | 0.81 | GRM5 (0.84) | GRM5CLPPMEN1KMT2APOLB | |
| SCHEMBL2740572 | 0.80 | GRM5 (0.61) | GRM5CLPPMEN1KMT2APOLB | |
| SCHEMBL192099 | 0.80 | GRM5 (1.00) | GRM5CLPPMEN1KMT2APOLB | |
| SCHEMBL193680 | 0.80 | GRM5 (1.00) | GRM5CLPPMEN1KMT2APOLB | |
| SCHEMBL192098 | 0.80 | GRM5 (1.00) | GRM5CLPPMEN1KMT2APOLB | |
| SCHEMBL4130488 | 0.80 | POLB (0.85) | GRM5CLPPMEN1KMT2APOLB | |
| SCHEMBL4130492 | 0.80 | POLB (0.85) | GRM5CLPPMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2030970-B1 | Allosteric modulators of metabotropic glutamate receptors | ADDEX PHARMACEUTICALS SA (CH) | 2012-01-04 | — | — | EP | disclosed |