Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | IL2 | P60568 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7824728 | 0.91 | NPC1 (0.47) | KDM4EIL2NPC1RAB9APDK2 | |
| SCHEMBL8873929 | 0.89 | EGFR (0.44) | KDM4EIL2NPC1RAB9AL3MBTL1 | |
| SCHEMBL7830474 | 0.86 | KDM4E (0.42) | KDM4EIL2MAPTALDH1A1LMNA | |
| SCHEMBL7827566 | 0.79 | HRH3 (0.46) | KDM4EIL2MAPTLMNAHTT | |
| SCHEMBL7827303 | 0.78 | CA12 (0.50) | KDM4EIL2PDK2 | |
| SCHEMBL600205 | 0.78 | NPC1 (0.47) | KDM4EIL2NPC1RAB9ATDP1 | |
| SCHEMBL8873328 | 0.77 | RARB (0.50) | KDM4EIL2NPC1RAB9AMAPT | |
| SCHEMBL18380643 | 0.77 | KDM4E (0.61) | KDM4EMAPTALDH1A1LMNAHTT | |
| SCHEMBL29616919 | 0.77 | KDM4E (0.61) | KDM4EMAPTALDH1A1LMNAHTT | |
| SCHEMBL8873995 | 0.76 | PDK2 (0.43) | KDM4EIL2NPC1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1080257-C | Guanidine derivatives as inhibitors of Na+/H+ exchange in cells | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-03-06 | — | — | CN | disclosed |
| CN-1123545-A | Guanidine derivatives as inhibitors of Na+/H+ exchange in cells | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-05-29 | — | — | CN | disclosed |