Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 14/20 | 0.50 |
| ▸ | JAK1 | P23458 | 11/20 | 0.48 |
| ▸ | JAK2 | O60674 | 10/20 | 0.48 |
| ▸ | TYK2 | P29597 | 4/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27418635 | 1.00 | JAK3 (0.50) | JAK3JAK1JAK2TYK2HDAC3 | |
| SCHEMBL31711639 | 0.92 | JAK3 (0.52) | JAK3JAK1JAK2TYK2HDAC3 | |
| SCHEMBL27418733 | 0.92 | JAK3 (0.52) | JAK3JAK1JAK2TYK2HDAC3 | |
| SCHEMBL27418652 | 0.92 | JAK3 (0.52) | JAK3JAK1JAK2TYK2HDAC3 | |
| SCHEMBL31711617 | 0.92 | JAK3 (0.52) | JAK3JAK1JAK2TYK2HDAC3 | |
| SCHEMBL27415143 | 0.91 | JAK3 (0.60) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL27415211 | 0.91 | JAK3 (0.60) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL31711634 | 0.91 | JAK3 (0.60) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL27419078 | 0.91 | JAK3 (0.50) | JAK3JAK1JAK2TYK2USP2 | |
| SCHEMBL31711643 | 0.90 | JAK3 (0.49) | JAK3JAK1JAK2TYK2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024137548-A2 | INHIBITORS OF JAK2 | Llydaw Therapeutics, Inc. (US) | 2024-06-27 | — | — | WO | disclosed |