Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 17/20 | 0.44 |
| ▸ | JAK3 | P52333 | 16/20 | 0.44 |
| ▸ | JAK2 | O60674 | 14/20 | 0.44 |
| ▸ | TYK2 | P29597 | 5/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31711635 | 1.00 | JAK1 (0.44) | JAK1JAK3JAK2TYK2KCNH2 | |
| SCHEMBL27415316 | 0.94 | JAK3 (0.52) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL31711658 | 0.94 | JAK3 (0.52) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL31711628 | 0.92 | JAK1 (0.46) | JAK1JAK3JAK2TYK2KCNH2 | |
| SCHEMBL27419238 | 0.92 | JAK3 (0.51) | JAK1JAK3JAK2TYK2KCNH2 | |
| SCHEMBL27418569 | 0.92 | JAK1 (0.46) | JAK1JAK3JAK2TYK2KCNH2 | |
| SCHEMBL31711618 | 0.92 | JAK3 (0.51) | JAK1JAK3JAK2TYK2KCNH2 | |
| SCHEMBL27418945 | 0.92 | JAK1 (0.43) | JAK1JAK3JAK2TYK2KCNH2 | |
| SCHEMBL31711621 | 0.90 | JAK2 (0.54) | JAK1JAK3JAK2TYK2KCNH2 | |
| SCHEMBL27418883 | 0.90 | JAK2 (0.54) | JAK1JAK3JAK2TYK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024137548-A2 | INHIBITORS OF JAK2 | Llydaw Therapeutics, Inc. (US) | 2024-06-27 | — | — | WO | disclosed |