Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 16/20 | 0.50 |
| ▸ | TYK2 | P29597 | 12/20 | 0.50 |
| ▸ | JAK3 | P52333 | 10/20 | 0.50 |
| ▸ | JAK2 | O60674 | 9/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31711651 | 1.00 | JAK1 (0.50) | JAK1TYK2JAK3JAK2KCNH2 | |
| SCHEMBL27419039 | 0.92 | JAK1 (0.52) | JAK1TYK2JAK3JAK2KCNH2 | |
| SCHEMBL31711623 | 0.92 | JAK1 (0.52) | JAK1TYK2JAK3JAK2KCNH2 | |
| SCHEMBL27414754 | 0.91 | JAK3 (0.62) | JAK1TYK2JAK3JAK2 | |
| SCHEMBL31711661 | 0.91 | JAK3 (0.62) | JAK1TYK2JAK3JAK2 | |
| SCHEMBL27415323 | 0.91 | JAK3 (0.51) | JAK1TYK2JAK3JAK2AXL | |
| SCHEMBL31711674 | 0.88 | JAK1 (0.53) | JAK1TYK2JAK3JAK2KCNH2 | |
| SCHEMBL27419137 | 0.88 | JAK1 (0.53) | JAK1TYK2JAK3JAK2KCNH2 | |
| SCHEMBL31711659 | 0.83 | JAK1 (0.51) | JAK1TYK2JAK3JAK2KCNH2 | |
| SCHEMBL27420290 | 0.83 | JAK1 (0.51) | JAK1TYK2JAK3JAK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024137548-A2 | INHIBITORS OF JAK2 | Llydaw Therapeutics, Inc. (US) | 2024-06-27 | — | — | WO | disclosed |