Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.43 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 3/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27345370 | 0.84 | EGFR (0.50) | EGFRADORA3ADORA2AADORA1TNNI3K | |
| SCHEMBL8317473 | 0.81 | EGFR (0.56) | EGFRADORA3ADORA2AADORA1CDK1 | |
| SCHEMBL6482739 | 0.75 | FFAR1 (0.50) | FFAR1 | |
| SCHEMBL6476065 | 0.75 | FFAR1 (0.50) | FFAR1 | |
| SCHEMBL6476076 | 0.75 | FFAR1 (0.50) | FFAR1 | |
| SCHEMBL8799311 | 0.73 | EGFR (0.52) | EGFRTNNI3K | |
| SCHEMBL2782010 | 0.73 | EGFR (0.65) | EGFRTNNI3K | |
| SCHEMBL1387302 | 0.73 | EGFR (0.72) | EGFRTNNI3K | |
| SCHEMBL27323457 | 0.72 | EGFR (0.53) | EGFRTNNI3K | |
| SCHEMBL7777342 | 0.72 | EGFR (0.64) | EGFRTNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1047778-C | Pyrimido [5-4-d] pyrimidines, drugs containing these compounds, their use and process for preparing them | THOMAE GMBH DR K (DE) | 1999-12-29 | — | — | CN | disclosed |