Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | RHEB | Q15382 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30974167 | 0.90 | SIRT2 (0.47) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL28396605 | 0.88 | HTT (0.64) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL1170648 | 0.84 | KDM4E (0.61) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL5032566 | 0.83 | HSP90AA1 (0.53) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL2098919 | 0.83 | KDM4E (0.51) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL2759988 | 0.82 | KDM4E (0.48) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL29488678 | 0.82 | KDM4E (0.50) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL1193316 | 0.82 | RHEB (0.54) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL1202574 | 0.82 | KDM4E (0.50) | KDM4EALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL18782890 | 0.82 | KDM4E (0.50) | KDM4EALDH1A1LMNAHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024129780-A1 | BENZIMIDAZOLE DERIVATIVES AS GPX4 INHIBITORS | SONATA THERAPEUTICS, INC. (US) | 2024-06-20 | — | — | WO | disclosed |