Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.55 |
| ▸ | MTOR | P42345 | 12/20 | 0.46 |
| ▸ | RPTOR | Q8N122 | 7/20 | 0.46 |
| ▸ | MLST8 | Q9BVC4 | 7/20 | 0.46 |
| ▸ | RICTOR | Q6R327 | 6/20 | 0.46 |
| ▸ | MAPKAP1 | Q9BPZ7 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27430904 | 0.93 | PIK3CA (0.64) | PIK3CAMTORRPTORMLST8RICTOR | |
| SCHEMBL27429044 | 0.89 | PIK3CA (0.48) | PIK3CAMTORRPTORMLST8RICTOR | |
| SCHEMBL27429025 | 0.88 | PIK3CA (0.55) | PIK3CAMTORRPTORMLST8RICTOR | |
| SCHEMBL27429021 | 0.88 | PIK3CA (0.55) | PIK3CAMTORRPTORMLST8RICTOR | |
| SCHEMBL27429029 | 0.85 | PIK3CA (0.54) | PIK3CAMTORRPTORMLST8RICTOR | |
| SCHEMBL27428902 | 0.83 | PIK3CA (0.58) | PIK3CAMTORRPTORMLST8RICTOR | |
| SCHEMBL27431002 | 0.82 | PIK3CA (0.57) | PIK3CAMTORRPTORMLST8RICTOR | |
| SCHEMBL27428898 | 0.82 | PIK3CA (0.57) | PIK3CAMTORRPTORMLST8RICTOR | |
| SCHEMBL27428814 | 0.81 | PIK3CA (0.63) | PIK3CAMTORRPTORMLST8RICTOR | |
| SCHEMBL27431842 | 0.81 | PIK3CA (0.70) | PIK3CAMTORRPTORMLST8RICTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240217960-A1 | TRIAZINE DERIVATIVE AS COVALENT INHIBITORS OF PI3K | UNIVERSITÄT BASEL (CH) | 2024-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240217960-A1 | TRIAZINE DERIVATIVE AS COVALENT INHIBITORS OF PI3K | PIK3R5, PIK3R1, PIK3R2 | PIK3CA 12/4885MTOR 61/4885RPTOR 446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.