Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 6/20 | 0.40 |
| ▸ | PPARD | Q03181 | 6/20 | 0.40 |
| ▸ | PPARA | Q07869 | 6/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TLR2 | O60603 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27434694 | 1.00 | TSHR (0.48) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL27413718 | 1.00 | TSHR (0.48) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL27476446 | 1.00 | TSHR (0.48) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL27476444 | 1.00 | TSHR (0.48) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL27554015 | 0.83 | CYP2C19 (0.41) | TSHRLMNANFKB1PMP22CYP1A2 | |
| SCHEMBL9861918 | 0.82 | TSHR (0.50) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL251273 | 0.78 | CYP2C19 (0.53) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL7153147 | 0.78 | CYP2C19 (0.53) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL251179 | 0.78 | CYP2C19 (0.53) | TSHRLMNANFKB1PMP22GPR84 | |
| SCHEMBL278034 | 0.78 | CYP2C19 (0.53) | TSHRLMNANFKB1PMP22GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1105558-C | 2,2-dichloroalkane carboxylic acids, process for preparing the same, medicament containing the same and use for treating insulin resistance | ROCHE DIAGNOSTICS GMBH (DE) | 2003-04-16 | — | — | CN | disclosed |
| CN-1171050-A | 2, 2-Dichloroalkanecarboxylic acids, method for the production thereof, medicaments containing the same and use thereof for the treatment of insulin resistance | BOEHRINGER MANNHEIM GMBH (DE) | 1998-01-21 | — | — | CN | disclosed |