Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.72 |
| ▸ | DRD2 | P14416 | 1/20 | 0.61 |
| ▸ | DRD4 | P21917 | 1/20 | 0.61 |
| ▸ | AKT1 | P31749 | 2/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27436765 | 0.87 | NOTUM (0.70) | NOTUMDRD2DRD4AKT1PIK3CD | |
| SCHEMBL3895361 | 0.84 | NOTUM (1.00) | NOTUMDRD2DRD4AKT1PIK3CD | |
| SCHEMBL7984513 | 0.84 | NOTUM (0.78) | NOTUMDRD2DRD4AKT1PIK3CD | |
| SCHEMBL30730960 | 0.84 | NOTUM (1.00) | NOTUMDRD2DRD4AKT1PIK3CD | |
| SCHEMBL5568816 | 0.82 | NOTUM (0.76) | NOTUMDRD2DRD4AKT1PIK3CD | |
| SCHEMBL19436139 | 0.81 | NOTUM (0.49) | NOTUMDRD2DRD4AKT1PIK3CD | |
| SCHEMBL14842647 | 0.79 | MEN1 (0.62) | NOTUMDRD2DRD4AKT1PIK3CD | |
| SCHEMBL20905152 | 0.79 | NOTUM (0.70) | NOTUMDRD2DRD4AKT1PIK3CD | |
| SCHEMBL27442560 | 0.76 | NOTUM (0.53) | NOTUMDRD2DRD4AKT1PIK3CD | |
| SCHEMBL13390815 | 0.75 | NOTUM (0.68) | NOTUMDRD2DRD4AKT1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024133499-A1 | GLYCINE DERIVATIVES WITH P2X4 RECEPTOR-BLOCKING ACTIVITY AS DIAGNOSTICS AND FOR THE TREATMENT OF PAIN, INFLAMMATION, CANCER, AND OTHER P2X4 RECEPTOR-RELATED DISEASES | RHEINISCHE-FRIEDRICH-WILHELMS-UNIVERSITÄT BONN (DE) | 2024-06-27 | — | — | WO | disclosed |