Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 13/20 | 0.49 |
| ▸ | SMARCA4 | P51532 | 13/20 | 0.49 |
| ▸ | PBRM1 | Q86U86 | 14/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 6/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30796060 | 0.89 | SMARCA2 (0.47) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL27458402 | 0.89 | SMARCA2 (0.47) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL30796207 | 0.87 | SMARCA2 (0.51) | SMARCA2SMARCA4PBRM1 | |
| SCHEMBL27458085 | 0.83 | SMARCA2 (0.48) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL27261742 | 0.80 | SMARCA2 (0.50) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL30796712 | 0.79 | SMARCA2 (0.59) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL27458272 | 0.79 | SMARCA2 (0.59) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL31536353 | 0.79 | SMARCA2 (0.59) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL30796686 | 0.79 | SMARCA2 (0.59) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL27458561 | 0.79 | SMARCA2 (0.59) | SMARCA2SMARCA4PBRM1NR1I2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023244764-A1 | COMPOUNDS FOR THE TARGETED DEGRADATION OF SMARCA2 | C4 THERAPEUTICS, INC. (US) | 2023-12-21 | — | — | WO | disclosed |