Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.77 |
| ▸ | ERBB2 | P04626 | 13/20 | 0.77 |
| ▸ | GAK | O14976 | 2/20 | 0.61 |
| ▸ | STK4 | Q13043 | 2/20 | 0.61 |
| ▸ | SRC | P12931 | 2/20 | 0.60 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6383704 | 0.88 | EGFR (0.78) | EGFRERBB2STK4SRCMAP2K1 | |
| SCHEMBL95052 | 0.87 | EGFR (1.00) | EGFRERBB2GAKSTK4 | |
| SCHEMBL6382094 | 0.87 | EGFR (0.80) | EGFRERBB2GAKSTK4SRC | |
| SCHEMBL6382235 | 0.87 | EGFR (0.80) | EGFRERBB2GAKSTK4SRC | |
| SCHEMBL6380499 | 0.84 | EGFR (1.00) | EGFRERBB2GAKSRCMAP2K1 | |
| SCHEMBL6381507 | 0.84 | EGFR (0.82) | EGFRERBB2STK4 | |
| SCHEMBL6379850 | 0.84 | EGFR (1.00) | EGFRERBB2GAKSRCMAP2K1 | |
| SCHEMBL6384856 | 0.82 | EGFR (0.76) | EGFRERBB2GAKSRCMAP2K1 | |
| SCHEMBL6380110 | 0.82 | EGFR (0.77) | EGFRERBB2GAKSRCMAP2K1 | |
| SCHEMBL6385549 | 0.82 | EGFR (0.74) | EGFRERBB2GAKSRCMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1121391-C | Substituted 3-cyano quinolines | AMERICAN CYANAMID CO (US) | 2003-09-17 | — | — | CN | claimed |
| CN-1259125-A | Substituted 3-cyanoquinolines | AMERICAN CYANAMID CO (US) | 2000-07-05 | — | — | CN | claimed |