Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.48 |
| ▸ | CDK2 | P24941 | 6/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.47 |
| ▸ | GSK3A | P49840 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.46 |
| ▸ | CDK4 | P11802 | 2/20 | 0.46 |
| ▸ | CCND1 | P24385 | 2/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.46 |
| ▸ | CDK11A | Q9UQ88 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27463538 | 0.88 | NPC1 (0.47) | NPC1MEN1KMT2AMAPTTP53 | |
| SCHEMBL6635712 | 0.84 | CCNA2 (0.60) | NPC1MEN1KMT2AMAPTTP53 | |
| SCHEMBL5724658 | 0.84 | MEN1 (0.58) | NPC1MEN1KMT2AMAPTTP53 | |
| SCHEMBL5725144 | 0.82 | CCNA2 (0.70) | CCNA2CDK2CDK5CDK5R1GSK3A | |
| SCHEMBL5726238 | 0.80 | CCNA2 (0.57) | NPC1MEN1KMT2AMAPTTP53 | |
| SCHEMBL6631481 | 0.79 | DHODH (0.60) | NPC1MEN1KMT2AMAPTTP53 | |
| SCHEMBL5725641 | 0.78 | CDK4 (0.74) | CDK5GSK3AGSK3BCCNT1CDK4 | |
| SCHEMBL5725210 | 0.78 | CDK5 (0.48) | NPC1MEN1KMT2AMAPTTP53 | |
| SCHEMBL5726348 | 0.78 | CCNT1 (0.50) | NPC1MEN1KMT2AMAPTTP53 | |
| SCHEMBL5725481 | 0.76 | CDK4 (0.62) | CDK2CDK5GSK3AGSK3BCCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1158269-C | 4-aminothiazole derivs, their preparation and their use as inhibitors of cyclin-dependent kinases | ������ҩ������˾ | 2004-07-21 | — | — | CN | disclosed |
| CN-1276789-A | 4-aminothiazole derivatives, their preparation and their use as inhibitors of cyclin dependent kinases | AGOURON PHARMA (US) | 2000-12-13 | — | — | CN | disclosed |