Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 20/20 | 0.78 |
| ▸ | DDX5 | P17844 | 1/20 | 0.69 |
| ▸ | RECQL | P46063 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27477499 | 0.94 | TOP1 (0.77) | TOP1DDX5RECQLTDP1MEN1 | |
| SCHEMBL27461810 | 0.92 | TOP1 (0.74) | TOP1DDX5RECQLTDP1MEN1 | |
| SCHEMBL27477075 | 0.91 | TOP1 (0.84) | TOP1DDX5RECQLTDP1KDM4E | |
| SCHEMBL27477911 | 0.90 | TOP1 (0.71) | TOP1DDX5RECQLTDP1MEN1 | |
| SCHEMBL27479909 | 0.90 | TOP1 (0.79) | TOP1DDX5RECQLTDP1MEN1 | |
| SCHEMBL24684716 | 0.88 | TOP1 (1.00) | TOP1DDX5RECQLTDP1KDM4E | |
| SCHEMBL28177312 | 0.88 | TOP1 (1.00) | TOP1DDX5RECQLTDP1KDM4E | |
| SCHEMBL31689186 | 0.88 | TOP1 (1.00) | TOP1DDX5RECQLTDP1KDM4E | |
| SCHEMBL18296780 | 0.87 | TOP1 (1.00) | TOP1DDX5RECQLTDP1MEN1 | |
| SCHEMBL8487224 | 0.86 | TOP1 (0.78) | TOP1RECQLTDP1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1159192-A | Substituted camptothecin derivatives and process for their preparation | PHARMACIA & UPJOHN SPA (IT) | 1997-09-10 | — | — | CN | claimed |
| CN-1159192-A | Substituted camptothecin derivatives and process for their preparation | PHARMACIA & UPJOHN SPA (IT) | 1997-09-10 | — | — | CN | disclosed |