Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 20/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | RECQL | P46063 | 2/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | RAB9A | P51151 | 1/20 | 0.69 |
| ▸ | BLM | P54132 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | USP2 | O75604 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | CASP1 | P29466 | 2/20 | 0.65 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.65 |
| ▸ | CASP7 | P55210 | 2/20 | 0.65 |
| ▸ | HBB | P68871 | 2/20 | 0.65 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.65 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8482799 | 1.00 | TOP1 (0.77) | TOP1KDM4EMAPTRECQLTDP1 | |
| SCHEMBL27478767 | 0.93 | TOP1 (0.73) | TOP1KDM4EMAPTRECQLTDP1 | |
| SCHEMBL8486034 | 0.93 | TOP1 (0.73) | TOP1KDM4EMAPTRECQLTDP1 | |
| SCHEMBL8486328 | 0.93 | TOP1 (0.73) | TOP1KDM4EMAPTRECQLTDP1 | |
| SCHEMBL8483108 | 0.92 | TOP1 (0.78) | TOP1KDM4EMAPTRECQLTDP1 | |
| SCHEMBL27477908 | 0.92 | TOP1 (0.78) | TOP1KDM4EMAPTRECQLTDP1 | |
| SCHEMBL27479180 | 0.92 | TOP1 (0.72) | TOP1KDM4EMAPTRECQLTDP1 | |
| SCHEMBL8485179 | 0.91 | TOP1 (0.77) | TOP1KDM4EMAPTRECQLTDP1 | |
| SCHEMBL27463598 | 0.91 | TOP1 (0.77) | TOP1KDM4EMAPTRECQLTDP1 | |
| SCHEMBL8484963 | 0.89 | TOP1 (0.79) | TOP1KDM4EMAPTRECQLTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1159192-A | Substituted camptothecin derivatives and process for their preparation | PHARMACIA & UPJOHN SPA (IT) | 1997-09-10 | — | — | CN | claimed |
| CN-1159192-A | Substituted camptothecin derivatives and process for their preparation | PHARMACIA & UPJOHN SPA (IT) | 1997-09-10 | — | — | CN | disclosed |