Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 7/20 | 0.51 |
| ▸ | CDK2 | P24941 | 7/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.50 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 2/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.45 |
| ▸ | RELA | Q04206 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27609557 | 0.88 | CDK5 (0.58) | CCNA2CDK2CDK5CDK5R1NPC1 | |
| SCHEMBL27609672 | 0.87 | CCNA2 (0.56) | CCNA2CDK2CDK5CDK5R1NPC1 | |
| SCHEMBL27741436 | 0.86 | CDK5 (0.60) | CCNA2CDK2CDK5CDK5R1NPC1 | |
| SCHEMBL27477020 | 0.86 | NPC1 (0.51) | CCNA2CDK2CDK5CDK5R1NPC1 | |
| SCHEMBL27478332 | 0.84 | CCNA2 (0.61) | CCNA2CDK2CDK5CDK5R1MAPT | |
| SCHEMBL27591223 | 0.82 | CDK5 (0.58) | CCNA2CDK2CDK5CDK5R1LMNA | |
| SCHEMBL27591220 | 0.81 | SRD5A2 (0.52) | CCNA2CDK2CDK5CDK5R1KDM4E | |
| SCHEMBL27591227 | 0.81 | CDC7 (0.53) | CCNA2CDK2CDK5CDK5R1NPC1 | |
| SCHEMBL27609568 | 0.80 | CCNA2 (0.53) | CCNA2CDK2CDK5CDK5R1NPC1 | |
| SCHEMBL27762075 | 0.77 | MEN1 (0.58) | CCNA2CDK2CDK5CDK5R1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1158269-C | 4-aminothiazole derivs, their preparation and their use as inhibitors of cyclin-dependent kinases | ������ҩ������˾ | 2004-07-21 | — | — | CN | disclosed |
| CN-1276789-A | 4-aminothiazole derivatives, their preparation and their use as inhibitors of cyclin dependent kinases | AGOURON PHARMA (US) | 2000-12-13 | — | — | CN | disclosed |