SCHEMBL2746560

SCHEMBL2746560

CCCc1c(CC)cc(C(=O)Nc2ccccc2OC(C)=O)c(=O)n1CC1CCCCC1

nearest known ligand 0.50

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 16/20 0.50
CNR1 P21554 15/20 0.50
RXFP1 Q9HBX9 2/20 0.40
TP53 P04637 1/20 0.39
NR1I2 O75469 1/20 0.38
UGCG Q16739 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11906827 0.92 CNR2 (0.46) CNR2CNR1NR1I2UGCG
SCHEMBL2746869 0.89 CNR2 (0.51) CNR2CNR1RXFP1NR1I2UGCG
SCHEMBL11906828 0.87 CNR2 (0.41) CNR2CNR1
SCHEMBL2746565 0.85 CNR2 (0.49) CNR2CNR1TP53
SCHEMBL2745363 0.84 CNR2 (0.45) CNR2CNR1
SCHEMBL2746136 0.82 CNR2 (0.74) CNR2CNR1
SCHEMBL2747838 0.82 CNR2 (0.74) CNR2CNR1
SCHEMBL11908500 0.82 CNR2 (0.47) CNR2CNR1NR1I2UGCG
SCHEMBL5509900 0.79 CNR2 (0.51) CNR2CNR1
SCHEMBL11908503 0.77 CNR2 (0.43) CNR2CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1806342-B1 3-CARBAMOYL-2-PYRIDONE DERIVATIVE SHIONOGI & CO (JP) 2013-04-17 EP disclosed
US-8178681-B2 methyl 3-methyl-2-{[2-oxo-1-(2-oxo-ethyl)-1,2,5,6,7,8,9,10-octahydro-cycloocta[b]pyridine-3-carbonyl]-amino}-butyrate; cannabinoid receptor agonist; antiinflammatory agent, immunostimulant, analgesic; atopic dermatitis; excellent in photostability, and have excellent transdermal and oral absorbency SHIONOGI & CO., LTD. (JP) 2012-05-15 US disclosed
US-20080103139-A1 3-Carbamoyl-2-Pyridone Derivative SHIONOGI & CO. LTD. (JP) 2008-05-01 US disclosed
EP-1806342-A1 3-CARBAMOYL-2-PYRIDONE DERIVATIVE SHIONOGI & CO., LTD. (JP) 2007-07-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080103139-A1 3-Carbamoyl-2-Pyridone Derivative CNR1, CNR2, HRH4 CNR2 2/4885CNR1 1/4885RXFP1 256/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.