Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 17/20 | 0.79 |
| ▸ | MAPK9 | P45984 | 15/20 | 0.79 |
| ▸ | PRKD3 | O94806 | 15/20 | 0.79 |
| ▸ | MAP4K4 | O95819 | 15/20 | 0.79 |
| ▸ | CSNK1A1 | P48729 | 12/20 | 0.79 |
| ▸ | PRKD2 | Q9BZL6 | 12/20 | 0.79 |
| ▸ | MAPK8 | P45983 | 10/20 | 0.79 |
| ▸ | GSK3B | P49841 | 10/20 | 0.79 |
| ▸ | CSNK1G3 | Q9Y6M4 | 8/20 | 0.79 |
| ▸ | CSNK1G2 | P78368 | 7/20 | 0.79 |
| ▸ | CSNK1G1 | Q9HCP0 | 4/20 | 0.79 |
| ▸ | MINK1 | Q8N4C8 | 12/20 | 0.59 |
| ▸ | TAOK1 | Q7L7X3 | 8/20 | 0.59 |
| ▸ | EGFR | P00533 | 3/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.59 |
| ▸ | MAP4K5 | Q9Y4K4 | 5/20 | 0.56 |
| ▸ | LIMK1 | P53667 | 4/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.56 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2745733 | 0.92 | CSNK1D (0.76) | CSNK1DMAPK9PRKD3MAP4K4CSNK1A1 | |
| SCHEMBL12023484 | 0.88 | MAPK9 (1.00) | CSNK1DMAPK9PRKD3MAP4K4CSNK1A1 | |
| SCHEMBL2745079 | 0.84 | MAPK9 (0.71) | CSNK1DMAPK9PRKD3MAP4K4CSNK1A1 | |
| SCHEMBL2746009 | 0.83 | MAPK9 (0.70) | CSNK1DMAPK9PRKD3MAP4K4CSNK1A1 | |
| SCHEMBL2745911 | 0.80 | MAPK9 (0.73) | CSNK1DMAPK9PRKD3MAP4K4CSNK1A1 | |
| SCHEMBL1728723 | 0.77 | MAPK9 (0.80) | CSNK1DMAPK9PRKD3MAP4K4CSNK1A1 | |
| SCHEMBL4300868 | 0.74 | MAP4K4 (0.55) | CSNK1DMAPK9PRKD3MAP4K4CSNK1A1 | |
| SCHEMBL3523159 | 0.74 | MAPK9 (1.00) | CSNK1DMAPK9PRKD3MAP4K4CSNK1A1 | |
| SCHEMBL3818285 | 0.73 | MAP4K4 (0.77) | CSNK1DMAPK9PRKD3MAP4K4CSNK1A1 | |
| SCHEMBL12023290 | 0.73 | PRKD3 (0.74) | CSNK1DMAPK9PRKD3MAP4K4CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178672-B2 | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 MAP kinase | ARQULE, INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-8178672-B2 | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 MAP kinase | ARQULE, INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-8178672-B2 | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 MAP kinase | ARQULE, INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-20110301160-A1 | Inhibitors of P38 and Methods of Using the Same | ARQULE, INC. (US) | 2011-12-08 | — | — | US | disclosed |
| US-20110301160-A1 | Inhibitors of P38 and Methods of Using the Same | ARQULE, INC. (US) | 2011-12-08 | — | — | US | disclosed |
| EP-1633758-B1 | IMIDAZOTHIAZOLES AND IMIDAZOXAZOLE DERIVATIVES AS INHIBITORS OF P38 | ARQULE INC (US) | 2011-11-23 | — | — | EP | disclosed |
| US-7902192-B2 | Inhibitors of P38 and methods of using the same | ARQULE, INC. (US) | 2011-03-08 | — | — | US | disclosed |
| EP-2258704-A1 | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase | ArQule, Inc. (US) | 2010-12-08 | — | — | EP | disclosed |
| EP-2258704-A1 | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase | ArQule, Inc. (US) | 2010-12-08 | — | — | EP | disclosed |
| US-20090111985-A1 | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase | ARQULE, INC. | 2009-04-30 | — | — | US | disclosed |
| US-20090111985-A1 | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase | ARQULE, INC. | 2009-04-30 | — | — | US | disclosed |
| US-20090111985-A1 | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase | ARQULE, INC. | 2009-04-30 | — | — | US | disclosed |
| US-20070270418-A1 | Inhibitors of P38 and Methods of Using the Same | ARQULE, INC. | 2007-11-22 | — | — | US | disclosed |
| EP-1809636-A1 | SYNTHESIS OF IMIDAZOOXAZOLE AND IMIDAZOTHIAZOLE INHIBITORS OF P38 MAP KINASE | ARQULE, INC. (US) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006044869-A1 | SYNTHESIS OF IMIDAZOOXAZOLE AND IMIDAZOTHIAZOLE INHIBITORS OF P38 MAP KINASE | ARQULE, INC. (US) | 2006-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270418-A1 | Inhibitors of P38 and Methods of Using the Same | MAPK1, MAPK8, MAPK7 | CSNK1D 1438/4885MAPK9 31/4885PRKD3 541/4885 |
| US-20090111985-A1 | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase | MAPK1, MAPK14, MAPK15 | CSNK1D 499/4885MAPK9 39/4885PRKD3 607/4885 |
| US-20110301160-A1 | Inhibitors of P38 and Methods of Using the Same | MAPK1, MAPK7, MAPK8 | CSNK1D 1278/4885MAPK9 35/4885PRKD3 507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.