Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27470245 | 0.99 | HRH3 (0.40) | HRH3LTA4HPDE4AMAPK1PDE4B | |
| SCHEMBL2245482 | 0.89 | HRH3 (0.41) | HRH3LTA4HPDE4AMAPK1PDE4B | |
| SCHEMBL5270104 | 0.89 | HRH3 (0.41) | HRH3LTA4HPDE4AMAPK1PDE4B | |
| Bromide SCHEMBL6132805 | 0.84 | HRH3 (0.41) | HRH3LTA4HPDE4AMAPK1PDE4B | |
| SCHEMBL27508444 | 0.84 | HTR2A (0.43) | HRH3LTA4HPDE4AMAPK1PDE4B | |
| Hydrochloric Acid SCHEMBL27519893 | 0.83 | HTR2A (0.42) | HRH3LTA4HPDE4AMAPK1PDE4B | |
| Bromide SCHEMBL5369378 | 0.82 | HTR2A (0.50) | HRH3LTA4H | |
| SCHEMBL27471263 | 0.82 | SSTR1 (0.41) | HRH3LTA4H | |
| Bromide SCHEMBL6132803 | 0.81 | HRH3 (0.41) | HRH3LTA4HPDE4AMAPK1PDE4B | |
| SCHEMBL28746746 | 0.79 | HRH3 (0.43) | HRH3LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1152877-C | Piperazine derivatives | ����ҩƷ��ҵ��ʽ���� | 2004-06-09 | — | — | CN | disclosed |
| CN-1334812-A | Piperazine derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-02-06 | — | — | CN | disclosed |