Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.55 |
| ▸ | PPARD | Q03181 | 5/20 | 0.55 |
| ▸ | PPARA | Q07869 | 5/20 | 0.55 |
| ▸ | F7 | P08709 | 5/20 | 0.55 |
| ▸ | F3 | P13726 | 5/20 | 0.55 |
| ▸ | TERT | O14746 | 3/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | FABP4 | P15090 | 3/20 | 0.55 |
| ▸ | TOP1 | P11387 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | BLM | P54132 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.55 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.55 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.55 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oleic Acid SCHEMBL19899174 | 0.74 | PPARG (0.85) | PPARGPPARDPPARAF7F3 | |
| Oleic Acid SCHEMBL21647155 | 0.74 | PPARG (0.85) | PPARGPPARDPPARAF7F3 | |
| SCHEMBL22608051 | 0.74 | PPARG (1.00) | PPARGPPARDPPARAF7F3 | |
| Oleic Acid SCHEMBL20975500 | 0.74 | PPARG (1.00) | PPARGPPARDPPARAF7F3 | |
| SCHEMBL22608055 | 0.74 | PPARG (1.00) | PPARGPPARDPPARAF7F3 | |
| Palmitoleic Acid SCHEMBL25293293 | 0.74 | PPARG (1.00) | PPARGPPARDPPARAF7F3 | |
| Vaccenic Acid SCHEMBL25298899 | 0.74 | PPARG (1.00) | PPARGPPARDPPARAF7F3 | |
| Oleic Acid SCHEMBL25289881 | 0.74 | PPARG (1.00) | PPARGPPARDPPARAF7F3 | |
| SCHEMBL25424711 | 0.74 | PPARG (1.00) | PPARGPPARDPPARAF7F3 | |
| SCHEMBL22608052 | 0.74 | PPARG (1.00) | PPARGPPARDPPARAF7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109999012-A | A kind of Pramipexole transdermal patch and preparation method thereof | 大道隆达（北京）医药科技发展有限公司 | 2019-07-12 | — | — | CN | claimed |
| CN-101518599-A | Slow-release patch with daphne giraldii bark extract, and preparation method thereof | UNIV SHENYANG PHARMACEUTICAL | 2009-09-02 | — | — | CN | claimed |
| CN-101455730-A | Kusnezoff monkshood root and long pepper composition patch and preparation method thereof | UNIV SHENYANG PHARMACEUTICAL (CN) | 2009-06-17 | — | — | CN | claimed |
| CN-109999012-A | A kind of Pramipexole transdermal patch and preparation method thereof | 大道隆达（北京）医药科技发展有限公司 | 2019-07-12 | — | — | CN | disclosed |
| CN-102283820-B | Granisetron transdermal patch and preparation method thereof | UNIV SHENYANG PHARMACEUTICAL | 2014-06-25 | — | — | CN | disclosed |
| CN-103417517-A | Hapagoside adhesive skin patch and preparation method thereof | SHI KEYONG | 2013-12-04 | — | — | CN | disclosed |
| CN-101716163-B | Letrozole targeted slow-release transdermal patch and preparation method thereof | UNIV SHENYANG PHARMACEUTICAL | 2013-07-31 | — | — | CN | disclosed |
| CN-102283820-A | Granisetron transdermal patch and preparation method thereof | — | 2011-12-21 | — | — | CN | disclosed |
| CN-101518599-A | Slow-release patch with daphne giraldii bark extract, and preparation method thereof | UNIV SHENYANG PHARMACEUTICAL | 2009-09-02 | — | — | CN | disclosed |
| CN-101455730-A | Kusnezoff monkshood root and long pepper composition patch and preparation method thereof | UNIV SHENYANG PHARMACEUTICAL (CN) | 2009-06-17 | — | — | CN | disclosed |
| CN-1089469-A | Be used for the lasting two-phase matrix that discharges the transporter of medicine | CYGNUS THERAPEUTIC SYSTEMS (US) | 1994-07-20 | — | — | CN | disclosed |