Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1762358 | 0.79 | TSHR (0.52) | TSHRCYP3A4CA1CA2ALDH1A1 | |
| SCHEMBL203216 | 0.79 | TSHR (0.61) | TSHRCYP3A4GAAPOLBGLA | |
| SCHEMBL30574189 | 0.79 | TSHR (0.61) | TSHRCYP3A4GAAPOLBGLA | |
| SCHEMBL2132147 | 0.78 | TSHR (0.60) | TSHRCYP3A4CA1CA2TDP1 | |
| Fluoride SCHEMBL10883445 | 0.77 | TSHR (0.59) | TSHRCYP3A4GAAPOLBGLA | |
| Hydrochloric Acid SCHEMBL4383138 | 0.77 | TSHR (0.59) | TSHRCYP3A4GAAPOLBGLA | |
| Hydrochloric Acid SCHEMBL9827180 | 0.77 | TSHR (0.59) | TSHRCYP3A4GAAPOLBGLA | |
| SCHEMBL29417504 | 0.76 | — | — | |
| SCHEMBL203854 | 0.76 | — | — | |
| SCHEMBL28785557 | 0.76 | CYP3A4 (0.48) | TSHRCYP3A4CA1CA2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1156445-C | Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using isindoline derivatives | ��ʲ | 2004-07-07 | — | — | CN | disclosed |
| CN-1355790-A | Method for inhibiting amyloid aggregation and imaging amyloid deposits using isoindoline derivatives | WARNER LAMBERT CO (US) | 2002-06-26 | — | — | CN | disclosed |