Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 14/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 14/20 | 0.55 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.55 |
| ▸ | MPO | P05164 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5681543 | 0.87 | PDE3B (0.60) | PDE3BPDE3ATNNC1ALDH1A1KDM4E | |
| SCHEMBL5681538 | 0.87 | PDE3B (0.60) | PDE3BPDE3ATNNC1ALDH1A1KDM4E | |
| SCHEMBL5679347 | 0.85 | PDE3B (0.55) | PDE3BPDE3ATNNC1ALDH1A1KDM4E | |
| SCHEMBL5679353 | 0.85 | PDE3B (0.55) | PDE3BPDE3ATNNC1ALDH1A1KDM4E | |
| SCHEMBL6744002 | 0.84 | PDE3B (0.54) | PDE3BPDE3ATNNC1ALDH1A1KDM4E | |
| SCHEMBL6743999 | 0.84 | PDE3B (0.54) | PDE3BPDE3ATNNC1ALDH1A1KDM4E | |
| SCHEMBL5679283 | 0.84 | PDE3B (0.62) | PDE3BPDE3ATNNC1ALDH1A1KDM4E | |
| SCHEMBL5680478 | 0.84 | PDE3B (0.54) | PDE3BPDE3ATNNC1ALDH1A1KDM4E | |
| SCHEMBL5680473 | 0.84 | PDE3B (0.54) | PDE3BPDE3ATNNC1ALDH1A1KDM4E | |
| SCHEMBL5676756 | 0.80 | PDE3B (0.56) | PDE3BPDE3ATNNC1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1191241-C | Pyridazinylphenylhydrazones for anti-congestive heart failure | ORION CORP (FI) | 2005-03-02 | — | — | CN | disclosed |
| CN-1418196-A | Pyridazinylphenylhydrazones for anti-congestive heart failure | ORION CORP (FI) | 2003-05-14 | — | — | CN | disclosed |