Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.38 |
| ▸ | ITGAL | P20701 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27482110 | 1.00 | PLAU (0.41) | PLAURAB9ANPC1TDP1L3MBTL1 | |
| SCHEMBL8167167 | 0.90 | HPGD (0.50) | RAB9ANPC1L3MBTL1HPGDUSP2 | |
| SCHEMBL8167164 | 0.90 | HPGD (0.50) | RAB9ANPC1L3MBTL1HPGDUSP2 | |
| SCHEMBL27480960 | 0.89 | HPGD (0.52) | RAB9ANPC1L3MBTL1HPGDUSP2 | |
| SCHEMBL27480959 | 0.89 | HPGD (0.52) | RAB9ANPC1L3MBTL1HPGDUSP2 | |
| SCHEMBL8162792 | 0.85 | TP53 (0.41) | PLAURAB9ANPC1TDP1L3MBTL1 | |
| SCHEMBL8162796 | 0.85 | TP53 (0.41) | PLAURAB9ANPC1TDP1L3MBTL1 | |
| SCHEMBL8179170 | 0.74 | HPGD (0.48) | RAB9ANPC1HPGDUSP2LMNA | |
| SCHEMBL8179176 | 0.74 | HPGD (0.48) | RAB9ANPC1HPGDUSP2LMNA | |
| SCHEMBL6637459 | 0.74 | TP53 (0.41) | RAB9ANPC1L3MBTL1HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1535958-A | Alpha-substituted pyrimidine. thioalkyl and alkyl ether compound | �������Ŷ���Լ��������˾ | 2004-10-13 | — | — | CN | disclosed |
| CN-1152022-C | Alpha-substituted pyrimidine-thioalkyl and alkylether compounds | �������Ŷ���Լ��������˾ | 2004-06-02 | — | — | CN | disclosed |
| CN-1183773-A | Alpha-substituted pyrimidine-thioalkyl and alkylether compounds | UPJOHN CO (US) | 1998-06-03 | — | — | CN | disclosed |