Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 13/20 | 0.80 |
| ▸ | IGF1R | P08069 | 2/20 | 0.80 |
| ▸ | CDK1 | P06493 | 11/20 | 0.57 |
| ▸ | CDK4 | P11802 | 3/20 | 0.57 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.55 |
| ▸ | CDK9 | P50750 | 5/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.55 |
| ▸ | CDK7 | P50613 | 2/20 | 0.55 |
| ▸ | CCNH | P51946 | 2/20 | 0.55 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.55 |
| ▸ | MTOR | P42345 | 4/20 | 0.53 |
| ▸ | SMG1 | Q96Q15 | 4/20 | 0.53 |
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4314123 | 0.89 | CDK2 (1.00) | CDK2IGF1RCDK1CDK4CCNT1 | |
| SCHEMBL27475478 | 0.83 | CDK2 (0.72) | CDK2IGF1RCDK1CDK4CCNT1 | |
| SCHEMBL17943211 | 0.83 | CDK2 (0.77) | CDK2IGF1RCDK1CDK4IKBKB | |
| SCHEMBL16550119 | 0.82 | CDK2 (0.77) | CDK2IGF1RCDK1CDK4MAPK8 | |
| SCHEMBL1684897 | 0.82 | CDK2 (0.77) | CDK2IGF1RCDK1CDK4MAPK8 | |
| SCHEMBL1684782 | 0.82 | CDK2 (0.77) | CDK2IGF1RCDK1CDK4MAPK8 | |
| SCHEMBL1684802 | 0.82 | CDK2 (1.00) | CDK2IGF1RCDK1CDK4MAPK8 | |
| SCHEMBL16540727 | 0.82 | CDK2 (0.70) | CDK2IGF1RCDK1CDK4MAPK8 | |
| SCHEMBL17943223 | 0.82 | CDK2 (0.72) | CDK2IGF1RCDK1CDK4MAPK8 | |
| SCHEMBL7989223 | 0.81 | CDK2 (0.71) | CDK2IGF1RCDK1CDK4IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100415744-C | 2-arylamino-pyrimidines for the treatment of GSK3-related disorders | ASTRAZENECA AB (SE) | 2008-09-03 | — | — | CN | claimed |
| CN-1823064-A | 2-arylamino-pyrimidines for the treatment of GSK 3-related disorders | ASTRAZENECA AB (SE) | 2006-08-23 | — | — | CN | claimed |
| CN-100415744-C | 2-arylamino-pyrimidines for the treatment of GSK3-related disorders | ASTRAZENECA AB (SE) | 2008-09-03 | — | — | CN | disclosed |
| CN-1823064-A | 2-arylamino-pyrimidines for the treatment of GSK 3-related disorders | ASTRAZENECA AB (SE) | 2006-08-23 | — | — | CN | disclosed |
| CN-1174981-C | Imidazo [1, 2-A ] pyridine and pyrazolo [2, 3-A ] pyridine derivatives | — | 2004-11-10 | — | — | CN | disclosed |