Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 3/20 | 0.41 |
| ▸ | BRAF | P15056 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4336948 | 0.83 | MAPK14 (0.47) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL6028673 | 0.79 | MAPK14 (0.52) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL4329196 | 0.77 | MAPK14 (0.55) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL6028378 | 0.76 | MAPK14 (0.51) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL6028850 | 0.76 | MAPK14 (0.48) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL6028954 | 0.74 | MAPK3 (0.48) | MAPK14 | |
| SCHEMBL6029068 | 0.74 | HDAC6 (0.44) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL6028826 | 0.74 | MAPK14 (0.43) | MAPK14EGFRRAF1ADORA3ADORA2A | |
| SCHEMBL6028700 | 0.74 | MAPK14 (0.53) | MAPK14CSNK1DCSNK1E | |
| SCHEMBL6028891 | 0.74 | MAPT (0.50) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1281604-C | Substituted pyrazole compounds | TEIKOKU HORMONE MFG CO LTD (JP) | 2006-10-25 | — | — | CN | disclosed |
| CN-1560051-A | Substituted pyrazole compounds | �۹���ҩ��ʽ���� | 2005-01-05 | — | — | CN | disclosed |
| CN-1178931-C | Substituted pyrazole compounds | �۹���ҩ��ʽ���� | 2004-12-08 | — | — | CN | disclosed |
| CN-1353704-A | Substituted pyrazole compounds | TEIKOKU HORMONE MFG CO LTD (JP) | 2002-06-12 | — | — | CN | disclosed |