Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 9/20 | 0.66 |
| ▸ | EDNRB | P24530 | 7/20 | 0.66 |
| ▸ | FABP7 | O15540 | 1/20 | 0.47 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.47 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | P4HB | P07237 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.38 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27454128 | 0.93 | EDNRA (0.71) | EDNRAEDNRBFABP7FABP5LTA4H | |
| SCHEMBL27453264 | 0.90 | EDNRA (0.64) | EDNRAEDNRBFABP7FABP5LTA4H | |
| SCHEMBL7538261 | 0.86 | EDNRA (0.88) | EDNRAEDNRBFABP7FABP5LTA4H | |
| SCHEMBL27508611 | 0.81 | EDNRA (0.68) | EDNRAEDNRB | |
| SCHEMBL7589806 | 0.81 | EDNRA (1.00) | EDNRAEDNRBFABP7FABP5NPC1 | |
| SCHEMBL7586063 | 0.81 | EDNRA (1.00) | EDNRAEDNRBFABP7FABP5NPC1 | |
| SCHEMBL8676241 | 0.81 | EDNRA (1.00) | EDNRAEDNRBFABP7FABP5NPC1 | |
| SCHEMBL7586070 | 0.81 | EDNRA (1.00) | EDNRAEDNRBFABP7FABP5NPC1 | |
| SCHEMBL7586067 | 0.81 | EDNRA (1.00) | EDNRAEDNRBFABP7FABP5NPC1 | |
| SCHEMBL27544939 | 0.80 | EDNRA (0.59) | EDNRAEDNRBFABP7FABP5USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1145223-A | Endothelin receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1997-03-19 | — | — | CN | disclosed |