Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 11/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 11/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 11/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 11/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 11/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 11/20 | 0.45 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 5/20 | 0.38 |
| ▸ | GSAP | A4D1B5 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5967019 | 0.84 | PSEN1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL27539704 | 0.81 | ACE (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Propionic Acid SCHEMBL27539705 | 0.80 | ACE (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5967239 | 0.70 | SMYD3 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5966934 | 0.69 | XIAP (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6303318 | 0.69 | XIAP (0.42) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5967034 | 0.68 | SMYD3 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5967382 | 0.67 | SMYD3 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5967234 | 0.67 | PSEN1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4992626 | 0.67 | PSEN1 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1238779-A | Methods and compounds for inhibiting beta-amyloid peptide release and/or its synthesis | ELAN PHARM INC (US) | 1999-12-15 | — | — | CN | disclosed |