Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL293097 | 0.78 | — | — | |
| SCHEMBL27644423 | 0.73 | KCNA3 (0.41) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27482999 | 0.73 | — | — | |
| SCHEMBL27467944 | 0.70 | — | — | |
| SCHEMBL16288185 | 0.69 | — | — | |
| SCHEMBL2430952 | 0.69 | POLB (0.31) | — | |
| SCHEMBL2917543 | 0.69 | CYP2D6 (0.31) | CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4539262 | 0.69 | — | — | |
| SCHEMBL27515837 | 0.67 | — | — | |
| SCHEMBL10103535 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1322202-A | Quinazoline derivatives | ASTRA ZENECA N V (SE) | 2001-11-14 | — | — | CN | claimed |
| CN-100360505-C | Quinazoline derivatives as angiogenesis inhibitors | ASTRAZENECA AB (SE) | 2008-01-09 | — | — | CN | disclosed |
| CN-1315822-C | Quinoline derivatives having VEGF inhibiting activity | STRAZENECA AB (SE) | 2007-05-16 | — | — | CN | disclosed |
| CN-1252065-C | Cinnoline compounds | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | CN | disclosed |
| CN-1245402-C | indole derivatives, process for their preparation, pharmaceutical compositions containing them and their use | ASTRAZENECA AB (SE) | 2006-03-15 | — | — | CN | disclosed |
| CN-1597667-A | Quinazoline derivatives as angiogenesis inhibitors | ASTRAZENECA AB (SE) | 2005-03-23 | — | — | CN | disclosed |
| CN-1167422-C | Quinazoline derivatives as angiogenesis inhibitors | — | 2004-09-22 | — | — | CN | disclosed |
| CN-1161352-C | Quinazoline derivatives | — | 2004-08-11 | — | — | CN | disclosed |
| CN-1468230-A | Compound (I) | — | 2004-01-14 | — | — | CN | disclosed |
| CN-1446212-A | Quinoline derivatives having VEGF inhibiting activity | STRAZENECA AB (SE) | 2003-10-01 | — | — | CN | disclosed |
| CN-1446214-A | Cinnoline compounds | ASTRAZENECA AB (SE) | 2003-10-01 | — | — | CN | disclosed |
| CN-1346271-A | Quinazoline derivatives as angiogenesis inhibitors | ASTRAZENECA UK LTD (SE) | 2002-04-24 | — | — | CN | disclosed |
| CN-1322202-A | Quinazoline derivatives | ASTRA ZENECA N V (SE) | 2001-11-14 | — | — | CN | disclosed |