Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | APAF1 | O14727 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
| ▸ | TDP2 | O95551 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.31 |
| ▸ | GALK1 | P51570 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10059447 | 0.76 | ATM (0.42) | KDM4ENPC1LMNAMAPTHTT | |
| SCHEMBL3081572 | 0.71 | MKNK1 (0.41) | KDM4EAPAF1LMNAMAPTCASP3 | |
| SCHEMBL29349038 | 0.71 | KAT2B (0.43) | KDM4ENPC1LMNAMAPTHTT | |
| SCHEMBL3480507 | 0.70 | GCK (0.36) | KDM4EMAPTMAPK1KMT2A | |
| SCHEMBL8033703 | 0.68 | — | — | |
| SCHEMBL8285971 | 0.68 | ELANE (0.46) | KDM4E | |
| SCHEMBL28065853 | 0.67 | NOTUM (0.50) | KDM4ENPC1KDM4ALMNAMAPT | |
| SCHEMBL3078101 | 0.67 | KAT2B (0.48) | NPC1POLBMAPTHTTRECQL | |
| SCHEMBL5430590 | 0.65 | MAPKAPK2 (0.51) | KDM4EMAPTMAPK1RAB9AKMT2A | |
| SCHEMBL16570002 | 0.63 | CRBN (0.35) | KDM4EPOLBBLMDDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1131862-C | Pyrrolidinyl, piperidinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-12-24 | — | — | CN | disclosed |
| CN-1353708-A | Pyrrolidinyl-, piperidinyl-or homopiperidinyl-substituted (benzodioxan, benzofuran or benzopyran) derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2002-06-12 | — | — | CN | disclosed |