Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 13/20 | 0.71 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.71 |
| ▸ | NPC1 | O15118 | 5/20 | 0.68 |
| ▸ | RAB9A | P51151 | 5/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28356482 | 0.98 | EPHX1 (0.74) | EPHX2EPHX1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12474988 | 0.88 | EPHX2 (0.66) | EPHX2 | |
| SCHEMBL12474990 | 0.88 | EPHX2 (0.66) | EPHX2 | |
| SCHEMBL3961482 | 0.88 | EPHX2 (0.66) | EPHX2 | |
| SCHEMBL3345439 | 0.87 | EPHX2 (0.72) | EPHX2EPHX1 | |
| SCHEMBL2719754 | 0.87 | EPHX1 (0.70) | EPHX2EPHX1 | |
| SCHEMBL3958181 | 0.87 | EPHX2 (0.74) | EPHX2 | |
| SCHEMBL4176065 | 0.87 | EPHX2 (0.64) | EPHX2 | |
| SCHEMBL13756248 | 0.87 | EPHX1 (0.83) | EPHX2EPHX1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4232111 | 0.85 | EPHX2 (0.63) | EPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178570-B2 | Tie-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-20060293342-A1 | Tie-2 modulators and methods of use | EXELIXIS, INC. (US) | 2006-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293342-A1 | Tie-2 modulators and methods of use | TIE1, TEK, KDR | EPHX2 872/4885EPHX1 1178/4885NPC1 4467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.