Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 7/20 | 0.48 |
| ▸ | KDR | P35968 | 5/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.48 |
| ▸ | FLT1 | P17948 | 4/20 | 0.47 |
| ▸ | CBFB | Q13951 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | TERT | O14746 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27523123 | 0.86 | FGFR1 (0.43) | FGFR1KDRPDGFRBFLT1CBFB | |
| SCHEMBL1055259 | 0.85 | FGFR1 (0.58) | FGFR1KDRPDGFRBFLT1CBFB | |
| SCHEMBL27537643 | 0.81 | FGFR1 (0.51) | FGFR1KDRPDGFRBFLT1KCNH2 | |
| SCHEMBL27522017 | 0.80 | CBFB (0.45) | FGFR1KDRPDGFRBFLT1CBFB | |
| SCHEMBL4294962 | 0.80 | FGFR1 (0.59) | FGFR1KDRPDGFRBFLT1CBFB | |
| SCHEMBL27503214 | 0.79 | FGFR1 (0.48) | FGFR1KDRPDGFRBFLT1RET | |
| SCHEMBL3381705 | 0.79 | FGFR1 (0.72) | FGFR1KDRPDGFRBFLT1RET | |
| SCHEMBL3732791 | 0.77 | CDK1 (0.52) | KDRCBFBCDK1NPC1TP53 | |
| SCHEMBL27579484 | 0.74 | CBFB (0.47) | FGFR1KDRPDGFRBFLT1CBFB | |
| SCHEMBL27580195 | 0.72 | FLT3 (0.44) | FGFR1KDRPDGFRBFLT1CBFB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100526312-C | Benzimidazole quinolinones and uses thereof | CHIRON CORP (US) | 2009-08-12 | — | — | CN | disclosed |
| CN-1692112-A | Benzimidazole quinolinones and uses thereof | CHIRON CORP (US) | 2005-11-02 | — | — | CN | disclosed |
| CN-1659165-A | Quinolinone derivatives | CHIRON CORP (US) | 2005-08-24 | — | — | CN | disclosed |
| CN-1226283-A | Recombinant enzyme with dextranase activity | NOVO NORDISK AS (DK) | 1999-08-18 | — | — | CN | disclosed |