Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | ACACA | Q13085 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 5/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CCR9 | P51686 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5359174 | 0.89 | SYK (0.37) | PCSK9SYKBRD4AAK1MEN1 | |
| SCHEMBL5359170 | 0.89 | SYK (0.37) | PCSK9SYKBRD4AAK1MEN1 | |
| SCHEMBL28746070 | 0.89 | PCSK9 (0.36) | PCSK9SYKACACBACACAAAK1 | |
| SCHEMBL27573512 | 0.88 | AAK1 (0.38) | PCSK9SYKBRD4AAK1ALDH1A1 | |
| SCHEMBL27548075 | 0.88 | PCSK9 (0.36) | PCSK9SYKBRD4AAK1ALDH1A1 | |
| SCHEMBL28746073 | 0.86 | PCSK9 (0.39) | PCSK9SYKBRD4AAK1NQO2 | |
| SCHEMBL27550183 | 0.84 | AAK1 (0.37) | PCSK9SYKBRD4AAK1NQO2 | |
| SCHEMBL27522212 | 0.84 | PHGDH (0.35) | PCSK9SYKAAK1MEN1ALDH1A1 | |
| SCHEMBL27521700 | 0.81 | AAK1 (0.36) | PCSK9SYKAAK1ALDH1A1HPGD | |
| SCHEMBL27548104 | 0.81 | MEN1 (0.39) | PCSK9SYKBRD4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1277828-C | Piperzine devivs. | HOFFMANN LA ROCHE (CH) | 2006-10-04 | — | — | CN | disclosed |
| CN-1452622-A | Piperzine devivs. | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | CN | disclosed |