Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | EIF4A3 | P38919 | 2/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | DAO | P14920 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | RHEB | Q15382 | 2/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.39 |
| ▸ | F3 | P13726 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3094576 | 0.83 | HSD17B10 (0.56) | HPGDHSD17B10ALDH1A1MEN1USP2 | |
| SCHEMBL30817101 | 0.83 | HSD17B10 (0.56) | HPGDHSD17B10ALDH1A1MEN1USP2 | |
| SCHEMBL4040538 | 0.80 | CDK1 (0.54) | HPGDHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL28740680 | 0.80 | HPGD (0.53) | HPGDHSD17B10ALDH1A1MEN1USP2 | |
| SCHEMBL27896963 | 0.80 | HPGD (0.53) | HPGDHSD17B10ALDH1A1MEN1USP2 | |
| SCHEMBL3599395 | 0.80 | EIF4A3 (0.57) | HPGDHSD17B10ALDH1A1MEN1USP2 | |
| SCHEMBL3605104 | 0.80 | HPGD (0.53) | HPGDHSD17B10ALDH1A1MEN1USP2 | |
| SCHEMBL8985835 | 0.78 | HPGD (0.60) | HPGDHSD17B10ALDH1A1MEN1USP2 | |
| SCHEMBL6141633 | 0.76 | HRH4 (0.71) | HRH4 | |
| SCHEMBL3722103 | 0.76 | HSD17B10 (0.60) | HPGDHSD17B10ALDH1A1MEN1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1245405-C | Piperazine derivatives | HOFFMANN LA ROCHE (CH) | 2006-03-15 | — | — | CN | disclosed |
| CN-1529706-A | Piperazine derivatives | - | 2004-09-15 | — | — | CN | disclosed |