Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.57 |
| ▸ | LRRK2 | Q5S007 | 17/20 | 0.56 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27741317 | 0.84 | IKBKB (0.66) | IKBKBLRRK2CNR1CNR2GPR55 | |
| SCHEMBL5450217 | 0.83 | LRRK2 (0.56) | LRRK2MAPK11MAPK14 | |
| SCHEMBL2479766 | 0.83 | MAPK14 (0.44) | IKBKBLRRK2MAPK11MAPK14 | |
| SCHEMBL7852194 | 0.83 | MAPK11 (0.59) | LRRK2MAPK11MAPK14 | |
| SCHEMBL5446476 | 0.82 | IKBKB (0.57) | IKBKBLRRK2CNR1CNR2GPR55 | |
| SCHEMBL14519374 | 0.82 | LRRK2 (0.60) | LRRK2 | |
| SCHEMBL5255653 | 0.81 | LRRK2 (0.54) | LRRK2MAPK11MAPK14 | |
| SCHEMBL14521814 | 0.80 | MAPK14 (0.42) | IKBKBLRRK2MAPK11MAPK14 | |
| SCHEMBL5449961 | 0.78 | LRRK2 (0.54) | LRRK2MAPK14 | |
| SCHEMBL14519600 | 0.77 | MAPK14 (0.52) | MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1264377-A | Substituted pyrazoles as P38 kinase inhabitors | SEARLE & CO (US) | 2000-08-23 | — | — | CN | claimed |
| CN-1273603-A | Attenuated respiratory syncytial virus | AMERICAN CYANAMID CO (US) | 2000-11-15 | — | — | CN | disclosed |