Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5255779 | 0.89 | MAPK14 (0.53) | MAPK14MAPK11KCNH2SMN1; SMN2 | |
| Water SCHEMBL27580370 | 0.88 | MAPK14 (0.53) | MAPK14MAPK11KCNH2SMN1; SMN2MAPK13 | |
| Trifluoroacetic Acid SCHEMBL5260636 | 0.86 | MAPK14 (0.49) | MAPK14MAPK11KCNH2SMN1; SMN2 | |
| SCHEMBL5255770 | 0.85 | MAPK14 (0.45) | MAPK14MAPK11KCNH2SMN1; SMN2TLR8 | |
| SCHEMBL5255490 | 0.81 | MAPK14 (0.61) | MAPK14MAPK11MAPK13MAPK12 | |
| Water SCHEMBL5256024 | 0.80 | MAPK14 (0.59) | MAPK14MAPK11MAPK13MAPK12 | |
| Water SCHEMBL27580378 | 0.79 | MAPK14 (0.52) | MAPK14MAPK11KCNH2MAPK13MAPK12 | |
| SCHEMBL7854801 | 0.74 | MAPK14 (0.55) | MAPK14MAPK11KCNH2SMN1; SMN2MAPK13 | |
| SCHEMBL27555289 | 0.73 | MAPK14 (0.56) | MAPK14MAPK11SMN1; SMN2TSHRMAPK13 | |
| Water SCHEMBL27580375 | 0.72 | MAPK14 (0.70) | MAPK14MAPK11MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1342157-A | Substituted pyrazoles ASP38 kinase inhibitors | SEARLE & CO (US) | 2002-03-27 | — | — | CN | disclosed |