Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 9/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | STAT6 | P42226 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM5C | P41229 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3257066 | 0.75 | SYK (0.49) | KDM4ECAMK2D | |
| SCHEMBL27550354 | 0.72 | ABL1 (0.66) | — | |
| SCHEMBL3255280 | 0.72 | IKBKB (0.53) | BRAFCCNT1CCNA2CDK2CDK9 | |
| SCHEMBL1466635 | 0.70 | ABL1 (0.51) | BRAFCCNT1CCNA2CDK2CDK9 | |
| SCHEMBL13039322 | 0.69 | CCNT1 (0.60) | CCNT1CCNA2CDK2CDK9EIF2AK2 | |
| SCHEMBL4200006 | 0.68 | CCNT1 (0.59) | CCNT1CCNA2CDK2CDK9CAMK2D | |
| SCHEMBL28550605 | 0.68 | ABL1 (0.59) | CAMK2D | |
| SCHEMBL5256677 | 0.68 | MAPK14 (0.52) | CCNT1CCNA2CDK2CDK9MAPK14 | |
| SCHEMBL959130 | 0.68 | PTGDR (0.64) | CCNT1CCNA2CDK2CDK9KDM4E | |
| SCHEMBL3253355 | 0.67 | PIK3CG (0.47) | CCNT1CCNA2CDK2CDK9CAMK2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1330643-C | Phenyl-[4-(3-phenyl-1h-pyrazol-4-yl)-pyrimidin-2-yl)-amine derivatives | NOVARTIS AG (CH) | 2007-08-08 | — | — | CN | claimed |
| CN-1668610-A | Phenyl-[4-(3-phenyl-1h-pyrazol-4-yl)-pyrimidin-2-yl)-amine derivatives | NOVARTIS AG (CH) | 2005-09-14 | — | — | CN | claimed |