Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 18/20 | 0.62 |
| ▸ | CCND1 | P24385 | 18/20 | 0.62 |
| ▸ | CCND2 | P30279 | 16/20 | 0.62 |
| ▸ | CCND3 | P30281 | 16/20 | 0.62 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 5/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.44 |
| ▸ | CDK1 | P06493 | 3/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27578180 | 0.85 | CDK4 (0.63) | CDK4CCND1CCND2CCND3JAK3 | |
| SCHEMBL27578182 | 0.85 | CDK4 (0.56) | CDK4CCND1CCND2CCND3JAK3 | |
| SCHEMBL27577836 | 0.83 | CDK4 (0.63) | CDK4CCND1CCND2CCND3JAK3 | |
| SCHEMBL6803708 | 0.82 | CDK4 (0.67) | CDK4CCND1CCND2CCND3JAK3 | |
| SCHEMBL27595860 | 0.80 | CCND1 (0.60) | CDK4CCND1CCND2CCND3JAK3 | |
| SCHEMBL6812506 | 0.78 | CDK4 (0.76) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL5264058 | 0.78 | CDK4 (1.00) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL6809354 | 0.77 | CDK4 (0.72) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL6807928 | 0.76 | CDK4 (0.69) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL6812962 | 0.75 | CDK4 (0.74) | CDK4CCND1CCND2CCND3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1433417-A | Pyridopyrimidinone derivatives for treatment of neurodegenerative disease | WARNER LAMBERT CO (US) | 2003-07-30 | — | — | CN | claimed |
| CN-1433417-A | Pyridopyrimidinone derivatives for treatment of neurodegenerative disease | WARNER LAMBERT CO (US) | 2003-07-30 | — | — | CN | disclosed |